Rapidly Progressive Renal Failure and Multiple Primary Extranodal Involvement in a Patient with CD5 Positive Diffuse Large B Cell Lymphoma

Erdogmus S., Saral S., Ertop P., Aydin T., Kumru G., KAYGUSUZ G., ...More

TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL, vol.27, no.1, pp.104-107, 2018 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.5262/tndt.2018.1001.11
  • Journal Name: TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.104-107
  • Keywords: CD5 positive diffuse large B cell lymphoma, Primary extranodal lymphoma, Rapidly progressive renal failure, Renal biopsy, NON-HODGKINS-LYMPHOMAS
  • Ankara University Affiliated: Yes

Abstract

CD5 positive diffuse large B cell lymphoma is a very rare subtype of diffuse large B cell lymphoma with an aggressive lymphoid neoplasm. Extranodal involvement of lymphoma usually appears secondarily in the setting of disseminated disease, but the disease may originate from various extralymphatic organs. We present a case of primary extranodal lymphoma with coexistence of skin and renal involvement with rapidly progressive renal failure due to lymhpomatous infiltration. Renal biopsy revealed diffuse infiltration of the renal parenchyma by CD20+ atypical lymphoid cells. The patient was treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone. After the chemotherapy regimen, a dramatic improvement in the clinical picture was noticed.