THE ENDOTHELIUM-DERIVED RELAXING FACTOR-MEDIATED ACETYLCHOLINE RESPONSE OF THE ARTERIAL PERFUSION-PRESSURE AFTER COLD-STORAGE OF THE ISOLATED RABBIT KIDNEY

KUZU M. A., ALACAYIR I., KOKSOY C., YAZAR O., KUTERDEM E.

TRANSPLANT INTERNATIONAL, vol.8, no.3, pp.226-228, 1995 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 3
  • Publication Date: 1995
  • Journal Name: TRANSPLANT INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.226-228
  • Keywords: KIDNEY PRESERVATION, ENDOTHELIUM-DERIVED RELAXING FACTOR
  • Ankara University Affiliated: No

Abstract

The vasodilatation induced by acetylcholine (ACh) in a rabbit isolated perfused kidney was abolished when the tissue was exposed to cold ischemia for 72 h in Euro-Collins (EC) solution. This vasodilatation is due to the release of endothelium-derived relaxing factor (EDRF) from renal vasculature as evidenced by the attenuation following methylene blue pretreatment. When kidneys were preserved in EC solution containing UK 38 485. a thromboxane synthase inhibitor, or nicardipine, a calcium channel blocker, ACh-induced vasodilatation persisted after 72 h of cold ischemia. These results were taken as evidence of tissue protective activity of UK 38 385 and nicardipine and have promising implications for cadaveric kidney transplantation.