Intractable colitis associated with chronic granulomatous disease in a young girl

Yaman A., KULOĞLU Z., DOĞU E. F., İKİNCİOĞULLARI K. A., ENSARİ A., ÇİFTCİ E., ...More

TURKISH JOURNAL OF PEDIATRICS, vol.57, no.2, pp.189-191, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 2
  • Publication Date: 2015
  • Journal Name: TURKISH JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.189-191
  • Keywords: chronic granulomatous disease, colitis, children
  • Ankara University Affiliated: Yes

Abstract

Chronic granulomatous disease (CGD) is an autosomal recessive or X-linked disorder caused by NADPH oxidase deficiency leading to an impaired ability of reactive superoxide anion and metabolite formation and recurring severe bacterial and fungal infections, with a high mortality rate. Diarrhea, colitis, ileus, perirectal abscess formation and anal fissures are reported gastro-intestinal findings in these patients. We report a case of intractable colitis associated with CGD in a young girl.