Lesional activation of T(c)17 cells in Behcet disease and psoriasis supports HLA class I-mediated autoimmune responses


Vural S., Kerl K., Dogan P. E., Vollmer S., Puchta U., He M., ...More

BRITISH JOURNAL OF DERMATOLOGY, vol.185, no.6, pp.1209-1220, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 185 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.1111/bjd.20643
  • Journal Name: BRITISH JOURNAL OF DERMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1209-1220
  • Ankara University Affiliated: Yes

Abstract

Background Behcet disease (BD) presents with lymphocytic and neutrophilic vasculitis of unknown aetiology. HLA-B*51, the endoplasmic reticulum aminopeptidase 1 (ERAP1), and interleukin 23 receptor (IL23R)/IL12R are genetic risk factors. IL-23 regulates IL-17A, which controls the recruitment and activation of neutrophils.