Evaluation of hyaluronic matrix efficacy in sinus augmentation: a randomized-controlled histomorphometric and micro-computed tomography analysis

Dogan E., Dursun E., TOSUN E., Bilgic E., Akman A. C., ORHAN K., ...More

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, vol.46, no.7, pp.931-937, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 7
  • Publication Date: 2017
  • Doi Number: 10.1016/j.ijom.2017.03.003
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.931-937
  • Keywords: maxillary sinus augmentation, dental implant, hyaluronic matrix, histomorphometry, micro computed tomography, AUTOGENOUS BONE-GRAFTS, PORCINE BONE, FLOOR, ALLOGRAFT, CARRIER, HUMANS, ACID
  • Ankara University Affiliated: Yes


The objective of the present study was to test the hypothesis that the addition of hyaluronic acid-based matrix to collagenated heterologous bone graft for sinus augmentation would enhance bone formation compared to collagenated heterologous bone graft alone in the early healing period, by micro-computed tomography and histomorphometry. Thirteen systemically healthy patients requiring bilateral two-stage maxillary sinus augmentation (residual crest height <= 4 mm) were enrolled in this split-mouth prospective randomized controlled study. One sinus side as a control group was grafted with only collagenated heterologous bone graft; the other region as a test group was grafted with hyaluronic matrix and collagenated heterologous bone graft. Bone biopsy samples were taken after 4 months during the dental implant surgery and analyzed using micro-computed tomography and histomorphometric parameters. According to the micro-computed tomography and histomorphometric results, a significantly higher percentage of new bone was observed in the test group when compared to the control group after 4 months of healing.