Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode


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Bozal Palabıyık B.

Journal of the Turkish Chemical Society, Section A: Chemistry, vol.9, no.3, pp.751-758, 2022 (Peer-Reviewed Journal) identifier

Abstract

This study aims to offer a voltammetric method for determining the antipsychotic drug flupentixol from serum samples. According to pH and scan rate studies, the oxidation behavior of flupentixol at boron-doped diamond electrode was found as irreversible and diffusion-controlled. To determine flupentixol from bulk form and serum samples, differential pulse voltammetry was preferred as the working method because of the repeatability. Linear responses were obtained in the range of 6.0×10-7 – 8.0×10-6 M and 8.0×10-7 – 1.0×10-5 M for bulk form and serum samples in pH 2.0 Britton-Robinson buffer solution, with detection limit values of 1.09×10-7 M and 1.08×10-7 M, respectively. Required validation parameters were also studied and according to recovery from serum samples (99.91%) and precision studies, it can be inferred that the developed method was accurate and precise.