Synthesis, in vitro cytotoxic and antiviral activity of cis-[Pt(R(-) and S(+)-2-alpha,-hydroxybenzylbenzimidazole)(2)Cl-2] complexes

Gokce M., Utku S., Gur S., ÖZKUL A., Gumus F.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.40, no.2, pp.135-141, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1016/j.ejmech.2004.09.017
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.135-141
  • Keywords: 2-alpha-hydroxybenzylbenzin dazole, Pt(II) complexes, cytotoxic activity, antiviral activity, NUCLEOTIDE EXCISION-REPAIR, PLATINUM(II) COMPLEXES, PT(II) COMPLEXES, CISPLATIN, ANTITUMOR, DERIVATIVES, BINDING, RECOGNITION, RESISTANCE, SPECTRA
  • Ankara University Affiliated: Yes

Abstract

A pair of enantiomeric platinum(II) complexes of cis-[Pt(R(-) and S(+)-HBB)(2)Cl-2] (HBB = 2-alpha-hydroxybenzylbenzimidazole) was synthesized and evaluated for its preliminary in vitro cytotoxic activity on the human MCF-7 breast cancer and HeLa cervix cancer cell lines and antiherpes virus activity against bovine herpesvirus type 1 (BHV-1). In general, it was found that Pt(II) complexes were less cytotoxic on both cell lines than cisplatin and were comparable to carboplatin. There was no significant difference in cytotoxicity between two enantiomers, and the antiviral test results showed that the Pt(II) complexes and their carrier ligands R(-) and S(+) HBB had no effects inhibiting replication of BHV-1. (C) 2004 Elsevier SAS. All rights reserved.