Liquid-Phase Microextraction Approaches for Preconcentration and Analysis of Chiral Compounds: A Review on Current Advances

Bayatloo M. R., Tabani H., Nojavan S., Alexovič M., ÖZKAN S. A.

Critical Reviews in Analytical Chemistry, vol.53, no.8, pp.1623-1637, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 53 Issue: 8
  • Publication Date: 2023
  • Doi Number: 10.1080/10408347.2022.2038072
  • Journal Name: Critical Reviews in Analytical Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Environment Index, Geobase, MEDLINE, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.1623-1637
  • Keywords: Chiral compounds, enantiomer separation, enantioselective metabolism, liquid-phase microextraction, toxicokinetic, toxicodynamic mechanisms, MODIFIED CAPILLARY-ELECTROPHORESIS, SOLVENT-BASED MICROEXTRACTION, SUPRAMOLECULAR SOLVENTS, HUMAN PLASMA, ENANTIOSELECTIVE ANALYSIS, CHROMATOGRAPHIC DETERMINATION, PROPRANOLOL ENANTIOMERS, AMLODIPINE ENANTIOMERS, GAS-CHROMATOGRAPHY, SAMPLE PREPARATION
  • Ankara University Affiliated: Yes

Abstract

© 2022 Taylor & Francis Group, LLC.Chirality is a critical issue in pharmaceutics, forensic chemistry, therapeutic drug monitoring, doping control, toxicology, or environmental investigations as enantiomers of a chiral compound can exhibit different activities, i.e., one enantiomer can have the desired effect while the other one can be inactive or even toxic. To monitor enantioselective metabolism or toxicokinetic/toxicodynamic mechanisms in extremely low content in biological or environmental matrices, sample preparation is vital. The present review describes current status of development of liquid-phase microextraction approaches such as hollow fiber liquid-phase microextraction (HF-LPME), electromembrane extraction (EME), dispersive liquid-liquid microextraction (DLLME), and supramolecular solvent-based microextraction (SSME), used for sample preparation of enantiomers/chiral compounds. The advantages and limitations of the above techniques are discussed. Attention is also focused on chiral separation approaches commonly applied to study the stereo-selective metabolism or toxicokinetic/toxicodynamic mechanisms of enantiomers in the biological and environmental samples.