Gelsolin, NF-kappa B, and p53 expression in clear cell renal cell carcinoma: Impact on outcome

Kankaya D., KİREMİTCİ S., Tulunay O., BALTACI S.

PATHOLOGY RESEARCH AND PRACTICE, cilt.211, sa.7, ss.505-512, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 211 Sayı: 7
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.prp.2015.03.002
  • Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.505-512
  • Anahtar Kelimeler: Clear cell renal cell carcinoma, Gelsolin, Nuclear factor kappa B, p53, Prognosis, PROGNOSTIC-SIGNIFICANCE, CANCER, ACTIVATION, APOPTOSIS, SURVIVAL, PROGRESSION, NEPHRECTOMY, BORTEZOMIB, MUTATIONS, THERAPY
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives: To examine the prognostic significance of Gelsolin, NF-kappa B, and p53 in clear cell renal cell carcinoma (CRCC), which has an unpredictable behavior and tendency for recurrence and metastasis. Materials and methods: Immunohistochemistry was performed on 100 consecutive cases of CRCC using antibodies against Gelsolin, NF-kappa B, and p53. Tumors were grouped by nuclear grade (NG) as low NG (NG1, 2) or high NG (NG3, 4), and by pathological stage as localized (pT1, 2) or locally invasive (pT3, 4). Clinical stage was grouped as early stage (stage I, II) or late stage (stage III, IV). Evaluation was based on cytoplasmic (NF-kappa B-cyt) and nuclear (NF-kappa B-Nuc) expression for NF-kappa B, nuclear expression for p53, membranous and cytoplasmic expression for Gelsolin.