Novel bis-crown ethers and their sodium complexes as antimicrobial agent: synthesis and spectroscopic characterizations

HAYVALI Z., Guler H., Ogutcu H., SARI N.

MEDICINAL CHEMISTRY RESEARCH, vol.23, no.8, pp.3652-3661, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 8
  • Publication Date: 2014
  • Doi Number: 10.1007/s00044-014-0937-9
  • Journal Name: MEDICINAL CHEMISTRY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3652-3661
  • Keywords: bis-Crown ethers, Schiff bases, Aldehydes, Antibacterial activity, Sodium complexes, BIOLOGICAL-ACTIVITY, RECOGNITION SITES, ANTITUMOR, DERIVATIVES, EXTRACTION, SERIES, IONS
  • Ankara University Affiliated: Yes

Abstract

A series of new compounds containing formyl and imine group were synthesized. New formyl-substituted compounds were prepared by the reaction of 1,2-bis(bromomethyl)benzene with benzaldehyde derivatives in the presence of NaOH. New bis-crown ether imine compounds were prepared by the condensation of corresponding aldehydes with 4'-aminobenzo-15-crown-5. Sodium complexes of the bis-crown ethers form crystalline 2:1 (Na+:ligand) stoichiometries were also been synthesized. The prepared compounds were structurally confirmed by analytical and spectral data and evaluated for their antibacterial and antifungal activities. The results show that the antibacterial activity of compounds including o-methoxy group was significantly higher against S. epidermis compared to the other studied antimicrobial group.