CYTOGENETIC DAMAGE IN TURKISH COKE OVEN WORKERS EXPOSE l TO POLYCYCLIC AROMATIC HYDROCARBONS: ASSOCIATION WITH CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, AND GSTP1 GENE POLYMORPHISMS


ADA A. O., Demiroglu C., Yilmazer M., SÜZEN H. S., Demirbag A. E., Efe S., ...More

ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY, vol.64, no.3, pp.359-369, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.2478/10004-1254-64-2013-2328
  • Journal Name: ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.359-369
  • Keywords: chromosomal aberrations, biomarkers, micronuclei, occupational exposure, PERIPHERAL-BLOOD LYMPHOCYTES, CYTOKINESIS-BLOCK MICRONUCLEUS, MICROSOMAL EPOXIDE HYDROLASE, SISTER-CHROMATID EXCHANGES, OF-THE-LITERATURE, CANCER-RISK, CYTOCHROME-P450 1A1, POPULATION, BIOMARKERS, FREQUENCY
  • Ankara University Affiliated: Yes

Abstract

The aim of this study was to determine the frequencies of chromosomal aberrations (CA) and cytochalasin-blocked micronuclei (CBMN) in peripheral blood lymphocytes from Turkish coke oven workers and the influence of CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms on these biomarkers. Cytogenetic analysis showed that occupational exposure significantly increased the CA and CBMN frequencies. Gene polymorphisms, on the other hand, did not affect CA or CBMN in either exposed or control subjects. However, due to the limited sample size, our findings need to be verified in future studies with a larger sample.