Comparative Study for the Determination of Gemifloxacin by HPLC and Microbiological Methods from Pharmaceutical Preparations and Biological Samples

Kiymaci M. E., Gumustas A., Gümüştaş M., Akin A., Özkan S. A.

CURRENT PHARMACEUTICAL ANALYSIS, vol.11, no.3, pp.193-200, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.2174/1573412911666150305001657
  • Journal Name: CURRENT PHARMACEUTICAL ANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.193-200
  • Keywords: Gemifloxacin, HPLC, microbiology, validation, biological samples, pharmaceuticals, LIQUID-CHROMATOGRAPHY, DOSAGE FORMS, HUMAN SERUM, MESYLATE, FORMULATIONS, ASSAY, BULK, PHARMACOKINETICS, SUSCEPTIBILITY, VALIDATION
  • Ankara University Affiliated: Yes

Abstract

The fluoroquinolones have broad-spectrum activity, good absorption in gastrointestinal canals and superior tissue penetration. Because of these properties, they have been used to treat a wide range of infections. In this study high performance, liquid chromatography and microbiological methods have been developed for the determination of Gemifloxacin (GEM) in pharmaceutical preparations and human plasma.