CYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia.


Taspinar M., Aydos S. E., Comez O., ELHAN A. H., KARABULUT H. G., SUNGUROĞLU A.

Swiss medical weekly, vol.138, no.1-2, pp.12-7, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 138 Issue: 1-2
  • Publication Date: 2008
  • Journal Name: Swiss medical weekly
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.12-7
  • Keywords: CYP1A1, GSTT1, GSTM1, polymorphisms, CML, GLUTATHIONE-S-TRANSFERASE, CYTOCHROME P4501A1 POLYMORPHISMS, ACUTE LYMPHOBLASTIC-LEUKEMIA, PROSTATE-CANCER, COMBINED GENOTYPES, SUSCEPTIBILITY, M1, T1, TOBACCO, CYP2D6
  • Ankara University Affiliated: Yes

Abstract

Principles: Associations between polymorphisms for genes encoding enzymes involved in biotransformation of xenobiotics and susceptibility to several cancers have been shown in several studies. The aim of the present study is to investigate the influence of cytochromes P450 (CYP450) 1A1*2C and Glutathione S-transferases (GSTs) (T1 and M1) gene polymorphisms in susceptibility to chronic myeloid leukaemia (CML).