JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.22, no.6, pp.696-701, 2007 (SCI-Expanded)
Some novel benzimidazole derivatives were synthesized and their in vitro effects on rat liver microsomal NADPHdependent lipid peroxidation ( LP) level, ethoxyresorufin O-deethylase ( EROD) and antifungal activities were determined. A significant decrease in male rat liver microsomal LP level was noted by compounds 4c (52%), 4e (58%) and 4h (43%) at 10 23 M concentration. Compounds 4c (100.0%), 4h ( 100.0%), 5c (98.0%) and 5h (100.0%) inhibited the microsomal ethoxyresorufin O-deethylase ( EROD) enzyme activity better than that of the specific inhibitor caffeine (85%). Among these compounds, only compounds 4b and 4h exhibited moderate activity against C. albicans whereas the others had weak effects.