Synthesis, antifungal and antioxidant screening of some novel benzimidazole derivatives

Kerimov I., KILCIGİL G., EKE B., Altanlar N., Iscan M.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.22, no.6, pp.696-701, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1080/14756360701228558
  • Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.696-701
  • Keywords: thiosemicarbazides, thiadiazolylmethylbenzimidazoles, triazolylmethylbenzimidazoles, antimicrobial activity, antioxidant activity, lipid peroxidation, LIPID PEROXIDE FORMATION, LIVER
  • Ankara University Affiliated: Yes

Abstract

Some novel benzimidazole derivatives were synthesized and their in vitro effects on rat liver microsomal NADPHdependent lipid peroxidation ( LP) level, ethoxyresorufin O-deethylase ( EROD) and antifungal activities were determined. A significant decrease in male rat liver microsomal LP level was noted by compounds 4c (52%), 4e (58%) and 4h (43%) at 10 23 M concentration. Compounds 4c (100.0%), 4h ( 100.0%), 5c (98.0%) and 5h (100.0%) inhibited the microsomal ethoxyresorufin O-deethylase ( EROD) enzyme activity better than that of the specific inhibitor caffeine (85%). Among these compounds, only compounds 4b and 4h exhibited moderate activity against C. albicans whereas the others had weak effects.