Achievements of Graphene and Its Derivatives Materials on Electrochemical Drug Assays and Drug-DNA Interactions

Imanzadeh H., Bakirhan N. K., KURALAY F., Amiri M., ÖZKAN S. A.

Critical Reviews in Analytical Chemistry, vol.53, no.6, pp.1263-1284, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 53 Issue: 6
  • Publication Date: 2023
  • Doi Number: 10.1080/10408347.2021.2018568
  • Journal Name: Critical Reviews in Analytical Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Environment Index, Geobase, MEDLINE, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.1263-1284
  • Keywords: Graphene, sensors, direct electrochemistry, drug, drug-DNA interaction, GLASSY-CARBON ELECTRODE, SIMULTANEOUS VOLTAMMETRIC DETERMINATION, NANOCOMPOSITES MODIFIED ELECTRODE, COMPOSITE MODIFIED ELECTRODE, LABEL-FREE DETECTION, N-DOPED GRAPHENE, ASCORBIC-ACID, URIC-ACID, GOLD NANOPARTICLES, FUNCTIONALIZED-GRAPHENE
  • Ankara University Affiliated: Yes

Abstract

© 2021 Taylor & Francis Group, LLC.Graphene, emerging as a true two-dimensional (2D) material, has attracted increasing attention due to its unique physical and electrochemical properties such as high surface area, excellent conductivity, high mechanical strength, and ease of functionalization and mass production. The entire scientific community recognizes the significance and potential impact of graphene. Electrochemical detection strategies have advantages such as being simple, fast, and low-cost. The use of graphene as an excellent interface for electrode modification provides a promising way to construct more sensitive and stable electrochemical (bio)sensors. The review presents sensors based on graphene and its derivatives for electrochemical drug assays from pharmaceutical dosage forms and biological samples. Future perspectives in this rapidly developing field are also discussed. In addition, the interaction of several important anticancer drug molecules with deoxyribonucleic acid (DNA) that was immobilized onto graphene-modified electrodes has been detailed in terms of dosage regulation and utility purposes.