Risk factors for valproic acid induced hyperammonemia and its association with cognitive functions

DUMAN B., Can K. C., Agtas-Ertan E., ERDOĞAN S., İLHAN R. S., DOĞAN Ö., ...More

GENERAL HOSPITAL PSYCHIATRY, vol.59, pp.67-72, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59
  • Publication Date: 2019
  • Doi Number: 10.1016/j.genhosppsych.2019.05.005
  • Journal Name: GENERAL HOSPITAL PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.67-72
  • Keywords: Hyperammonemia, Valproic acid, Bipolar disorder, Epilepsy, Attention, Memory, ENCEPHALOPATHY
  • Ankara University Affiliated: Yes

Abstract

Objective: Valproic acid (VPA)-induced hyperammonemia (VIH), is an increase in blood ammonia levels without any alteration of hepatic enzymes, which can occur during VPA treatment. We aimed to determine the prevalence rate and the risk factors for VIH and its association with cognitive functions.