An intensive approach to the treatment of disseminated BCG infection in a SCID patient

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İKİNCİOĞULLARI K. A., DOĞU E. F., ÇİFTCİ E., Unal E., Ertem M., Reisli I., ...More

BONE MARROW TRANSPLANTATION, vol.30, no.1, pp.45-47, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1038/sj.bmt.1703578
  • Journal Name: BONE MARROW TRANSPLANTATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.45-47
  • Keywords: allogeneic BMT, SCID, disseminated BCG disease, SEVERE COMBINED IMMUNODEFICIENCY, TRANSPLANTATION, MARROW
  • Ankara University Affiliated: Yes

Abstract

There is an appreciable mortality associated with BMT in patients with SCID and advanced BCG infection. We present a girl with T-B+ SCID complicated by spina ventosa and disseminated BCG osteitis after receiving a fully matched sibling marrow transplant. Considerable progression characterised by two clinical activations and multiple pleural and perivertebral abscess formations occurred with conventional anti-mycobacterial chemotherapy. She finally recovered with full immune reconstitution after BMT and intensive treatment comprising five conventional and alternative agents that she received for 36 months. No side-effects and/or complications have been seen other than hearing loss.