Oxidative damage in the central nervous system and protection by melatoni̇n Santral si̇ni̇r si̇stemi̇ni̇n oksi̇dati̇f hasari ve melatoni̇n tarafindan korunmasi

ALAGÖZ Z., SÜZEN S.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.30, sa.3, ss.47-62, 2001 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 30 Sayı: 3
  • Basım Tarihi: 2001
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.47-62
  • Anahtar Kelimeler: Antioxidant, Free radical, Melatonin
  • Ankara Üniversitesi Adresli: Evet

Özet

Melatonin was recently reported to be an effective free radical scavenger and antioxidant. It is believed that melatonin scavenges the highly toxic hydroxyl radical, the peroxynitrite anion, and possibly the peroxyl radical. Also melatonin has been shown to reduce amyloid β protein toxicity of Alzheimer's disease and oxidative damage in several models of parkinson's disease. The role of melatonin as an antioxidant agent and protection against central nervous system diseases was investigated in this review.