Kanbes Dindar Ç., Demirtaş T. T., Uslu B.
Novel Nanostructured Materials for Electrochemical Bio-Sensing Applications, Jamballi G. Manjunatha, Editör, Elsevier Science, Oxford/Amsterdam , Amsterdam, ss.331-365, 2024
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Yayın Türü:
Kitapta Bölüm / Araştırma Kitabı
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Basım Tarihi:
2024
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Yayınevi:
Elsevier Science, Oxford/Amsterdam
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Basıldığı Şehir:
Amsterdam
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Sayfa Sayıları:
ss.331-365
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Editörler:
Jamballi G. Manjunatha, Editör
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Ankara Üniversitesi Adresli:
Evet
Özet
Abstract
Neurochemicals include
neurotransmitters, psychopharmaceuticals, and neuropeptides, all essential for neural activity. One of the fascinating topics of neuroscience research is how the amount and distribution of neurochemicals affect neurons, synapses, and neural networks and thus change the neurological process. Therefore detecting neurochemicals in biological fluids is critical for the diagnosis, treatment, and prognosis of neurological disease. Many relevant methods such as gas chromatography, high-performance liquid chromatography, capillary electrophoresis, mass spectroscopy, and Raman spectroscopy have been reported for the qualitative and quantitative determination of neurochemicals in several papers. The majority of these approaches require the use of expensive and sophisticated equipment, time-consuming pretreatment processes, complex sample preparations, and the use of organic compounds. However, it is possible to overcome these limitations with the use of electrochemical biosensing devices because measurements are made with a small sample amount, and the equipment is relatively inexpensive, fast, and simple. Also, nanostructured materials which are carbon-based nanomaterials, molecularly imprinted polymers, metal–organic frameworks, and metallic/metal oxide nanoparticles are also employed to improve the selectivity and sensitivity of electrochemical sensors. As a result, current advances and trends in neurochemical electrochemical detection techniques and the significance of nanostructured modification in electrochemical sensor investigations for neurochemical analysis are the subject of this chapter of the book. The composition and structure of nanostructured materials utilized in the study of neurochemicals are described and discussed in detail. Finally, the advantages, limitations, and prospects of nanostructured materials-modified electrodes in neurochemical analysis are presented to explain the benefits, challenges, and prospects of modification in electrochemical sensor studies for both in vitro and in vivo detection.