The relationship between semiquantitative parameters derived from technetium-99m metoxyisobutylisonitrile dual-phase parathyroid single-photon emission computed tomography images and disease severity in primary hyperparathyroidism

Cayir D., ARAZ M., Yalcindag A., Cakal E.

NUCLEAR MEDICINE COMMUNICATIONS, cilt.39, sa.4, ss.304-311, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1097/mnm.0000000000000803
  • Dergi Adı: NUCLEAR MEDICINE COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.304-311
  • Anahtar Kelimeler: parathyroid adenoma, primary hyperparathyroidism, single-photon emission-computed tomography, technetium-99m sestamibi, DIAGNOSTIC-VALUE, SESTAMIBI UPTAKE, SCINTIGRAPHY, ADENOMA, SPECT/CT, LOCALIZATION, TECHNETIUM-99M-SESTAMIBI, ULTRASOUND
  • Ankara Üniversitesi Adresli: Evet

Özet

ObjectiveThe relationship between multiple semiquantitative indices on technetium-99m metoxyisobutylisonitrile (Tc-99m MIBI) parathyroid single-photon emission computed tomography (SPECT) and clinical, laboratory, and radiological data was investigated in primary hyperparathyroidism.Patients and methodsNinety-three patients who had a histopathologically confirmed single parathyroid adenoma (PT) were enrolled. Regions of interests were drawn around the PT, neighboring thyroid (T), and background in early and late planar images and isocontour regions of interests around the adenoma in SPECT images (PT SPECT). The relationships between early and late PT, parathyroid adenoma counts/neighboring thyroid counts, parathyroid counts-thyroid counts (PT-T), PT washout, retention index, PT SPECT and serum parathormone (PTH), Ca, P, urinary Ca levels, weight of the adenoma, neck ultrasonography, renal ultrasonography, and bone mineral density findings were investigated.ResultsThere was a positive correlation between the weight of the adenoma and serum PTH and calcium (Ca) levels (P<0.001), between serum PTH and Ca levels (P<0.001), early PT-T and serum Ca levels (P=0.027), late PT-T and weight of the adenoma (P=0.04), and PT SPECT and serum Ca levels (P=0.046) and a reverse correlation between PT SPECT and serum phosphorus (P) levels (P=0.04). Serum Ca levels were significantly higher and P levels were lower in the group with PT SPECT values above 116. PT SPECT and late parathyroid adenoma counts/neighboring thyroid counts values were significantly higher in the group with serum Ca levels of more than 11mg/dl. Femoral T and Z scores were significantly lower in patients with lower PT washout. Early PT was significantly lower in patients with coexisting thyroiditis compared with patients with both thyroiditis and thyroid nodules (P=0.034).ConclusionSemiquantitative evaluation of a Tc-99m MIBI parathyroid SPECT study may help predict disease severity in primary hyperparathyroidism.