Do higher cut-off values for tuberculin skin test increase the specificity and diagnostic agreement with interferon gamma release assays in immunocompromised Bacillus Calmette-Guerin vaccinated patients?

EROL S., ÇİFTCİ F., ÇİLEDAĞ A., EROL S., ÖZDEMİR KUMBASAR Ö.

ADVANCES IN MEDICAL SCIENCES, cilt.63, sa.2, ss.237-241, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.advms.2017.12.001
  • Dergi Adı: ADVANCES IN MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.237-241
  • Anahtar Kelimeler: Latent tuberculosis infection, Immunocompromised, Tuberculin skin test, Solid organ transplantation, DETECTING LATENT TUBERCULOSIS, INFECTION, BCG, QUANTIFERON, PREVALENCE, PREVENTION, DISEASES
  • Ankara Üniversitesi Adresli: Evet

Özet

Purpose: Immunocompromised patients with latent tuberculosis infection (LTBI) are at high risk of progression to active tuberculosis. Detection and treatment of LTBI in this group of patients are very important to control active tuberculosis. Tuberculin skin test (TST) and interferon gamma release assays (IGRAs) are two methods for detection of LTBI. Diagnostic agreement between two tests are poor especially in Bacillus Calmette-Guerin (BCG) vaccinated immunocompromised patients. In this study, we tried to figure out if the use of a higher cut-off for TST increases diagnostic agreement with IGRAs and TST specificity and or not.