Synthesis of some 4-[3 ' or 4 '-(4H-4-oxo-1-benzopyran-2-yl)phenyl]-1,4-dihydropyridine derivatives as potential calcium channel antagonists

Tuncbilek M., Ertan R.

PHARMAZIE, vol.54, no.4, pp.255-259, 1999 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 4
  • Publication Date: 1999
  • Journal Name: PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.255-259
  • Ankara University Affiliated: Yes

Abstract

In this study, the synthesis of new flavonoid derivatives, which possess a 1,4-dihydropyridin (1,4-DHP) moiety on the phenyl ring of flavone were realized. 3' or 4'-Formyl-flavones were synthesized, then the aldehyde groups of these compounds were converted to the 1,4-DHP moiety by the Hantzsch method. A series of 23 new derivatives having different substituents at C-3 and C-5 of the 1,4-DHP ring were prepared. Two compounds (8a, 8b) were tested for their calcium channel blocker activity and 8b exhibited the best result.