The relationship between angiotensin converting enzyme gene I/D polymorphism and QT dispersion in patients with hypertrophic cardiomyopathy

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TULUNAY KAYA C., Gurlek A., Altin T., Kilickap M., KARABULUT H. G., Turhan S., ...More

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, vol.11, no.3, pp.192-197, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1177/1470320310368190
  • Journal Name: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.192-197
  • Keywords: ACE gene I/D polymorphism, arrhythmia, corrected QT dispersion, hypertrophic cardiomyopathy, QT dispersion, LEFT-VENTRICULAR HYPERTROPHY, INSERTION DELETION POLYMORPHISM, ABNORMALITIES, ENHANCEMENT, ARRHYTHMIAS, MORTALITY, GENOTYPE, INTERVAL, DISEASE, DEATH
  • Ankara University Affiliated: Yes

Abstract

Introduction: Hypertrophic cardiomyopathy (HCM) is characterized by disorganized myocardial architecture, and may cause ventricular arrhythmias and sudden death. The angiotensin-converting enzyme (ACE) with two deletion alleles (DD genotype) has been proposed to be associated with increased myocardial collagen content. We evaluated QT dispersion (QTd), which reflects regional differences in ventricular repolarization, in HCM patient and controls among the three different ACE genotypes.