Advances in electrochemical DNA biosensors and their interaction mechanism with pharmaceuticals

KURBANOĞLU S., DOĞAN TOPAL B., Plata Rodriguez E., BOZAL PALABIYIK B., ÖZKAN S. A., USLU B.

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, cilt.775, ss.8-26, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 775
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.jelechem.2016.05.022
  • Dergi Adı: JOURNAL OF ELECTROANALYTICAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.8-26
  • Anahtar Kelimeler: Electrochemistry, Biosensor, Interaction mechanism, Binding constant, Determination, GLASSY-CARBON ELECTRODE, PENCIL-GRAPHITE ELECTRODE, IN-SITU EVALUATION, ANTICANCER DRUG METHOTREXATE, NANOFIBER-MODIFIED ELECTRODE, SURFACE-CONFINED INTERACTION, SINGLE-STRANDED-DNA, CALF THYMUS DNA, MITOMYCIN-C, VOLTAMMETRIC DETERMINATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Studying the process of interaction between DNA and drugs became widespread in last more than ten years. In this regard, designing electrochemical DNA biosensors contributed to the development of more selective and sensitive electrochemical methods for the detection of specific DNA binding. This paper is based on the researches in the last years (between 2004 and 2015) focusing on the studies on electroanalytical interactions between dsDNA and drugs. Normal pulse, cyclic, differential pulse and square wave voltammetric methods were generally employed for analyzing drug and dsDNA oxidation signals through using various sensors and nanosensors. The researches on these fields are summarized as tables providing information about pH and medium of the study, sensor/nanosensor type, modes of mechanism and binding constant of drug-dsDNA interaction, the results expressed in the concentration range and also detection limits. (C) 2016 Elsevier B.V. All rights reserved.