Electrochemical Detectors in Liquid Chromatography: Recent Trends in Pharmaceutical and Biomedical Analysis

Kauffmann J., Bakirhan N. K., BOZAL PALABIYIK B., USLU B., Rodriguez Gomez R., Vandeput M., ...More

CURRENT MEDICINAL CHEMISTRY, vol.25, no.33, pp.4050-4065, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 25 Issue: 33
  • Publication Date: 2018
  • Doi Number: 10.2174/0929867324666170609074826
  • Journal Name: CURRENT MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4050-4065
  • Keywords: Liquid chromatography, electrochemical detector, biomedical, pharmaceutical analysis, bioanalysis, amperometry, SCREEN-PRINTED ELECTRODES, PULSED AMPEROMETRIC DETECTION, IMMOBILIZED ENZYME REACTORS, DOPED DIAMOND ELECTRODE, HUMAN PLASMA, PHENOLIC-COMPOUNDS, HPLC-ECD, GOLD ELECTRODES, BIOGENIC-AMINES, BRAIN-TISSUE
  • Ankara University Affiliated: Yes

Abstract

Liquid chromatography (LC) coupled to an electrochemical (EC) detector is a complementary analytical tool compared to LC coupled with optical or mass spectrometry detectors (LC-MS). LC-EC can be applied to the determination of molecules difficult to be analyzed by other commercially available detectors. New EC detector design and new working electrode material have extended the scope of application in the field of pharmaceutical compounds analysis. Combining EC with LC-MS offers additional advantages compared to optical detectors in terms of drug stability and drug metabolism mimicry studies. Selected literature devoted to pharmacologically active compounds in their dosage forms, herbal drugs in natural products, drug residues in feed and/or in biological samples are reported in this review.