Synthesis and antioxidant capacities of some new benzimidazole derivatives

KILCIGİL G., Kus C., Ozdamar E. D., EKE B., Iscan M.

ARCHIV DER PHARMAZIE, vol.340, no.11, pp.607-611, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 340 Issue: 11
  • Publication Date: 2007
  • Doi Number: 10.1002/ardp.200700088
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.607-611
  • Keywords: antioxidant activity, benzimidazoles, oxadiazoles, LIPID PEROXIDE FORMATION, INDOLE, LIVER
  • Ankara University Affiliated: Yes

Abstract

In this study, we prepared some new oxadiazolyl benzimidazole derivatives and investigated their antioxidant properties by determination of microsomal NADPH-dependent inhibition of lipid peroxidation levels (LP assay) and microsomal ethoxyresorufin 0-deethylase activity (EROD assay). Some of these compounds 20, 23 had slightly inhibitory effects (28%) on the lipid peroxidation levels at 10(-3)M concentration lower than standard BHT (65%). 5-[2-(Phenyl)-benzimidazol1-yl-methyl]-2-mercapto-[1,3,4]-oxadiazole 16 was found to be more active than caffeine on the ethoxyresorufm 0-deethylase activity with an IC50 value of 2.0 6 10(-4)M.