SYNTHESIS AND INHIBITORY ACTIVITIES ON PLATELET-AGGREGATION OF SOME FLAVONOID ANALOGS

GÖKER A. H., TUNCBILEK M., LEONCINI G., BUZZI E., MAZZEI M., ROLLAND Y., ...More

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, vol.45-1, no.2, pp.150-155, 1995 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45-1 Issue: 2
  • Publication Date: 1995
  • Journal Name: ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, International Pharmaceutical Abstracts
  • Page Numbers: pp.150-155
  • Keywords: BENZODIOXOLE, BENZODIOXANE, 4H-1-BENZOPYRAN-4-ONE, ANTIPLATELET ACTIVITY, PLATELET AGGREGATION, POSSESSING SPASMOLYTIC ACTIVITY, DERIVATIVES
  • Ankara University Affiliated: Yes

Abstract

A series of 26 benzodioxan and benzodioxol derivatives of flavone have been prepared. The activity of the compounds on washed human platelet aggregation induced by adenosine diphosphate (ADP, 5 mu mol/l), collagen (10 mu g/ml) and calcimycin (20 mu mol/l) was evaluated. The alkoxycarbonyl side chain derivatives inhibited all three types of aggregation inducers. Among the tested compounds 1a is the most potent inhibitor of collagen-induced aggregation but possesses a weak activity against the other t,wo used inducers. The esters IIIb and in particular, IIIc are active against all the three used inducers. These results suggest that ethoxycarbonyl group is a potent substituent to provide the antiplatelet action in this series of flavonoids.