Interleukin-28 gene polymorphisms may contribute to HBsAg persistence and the development of HBeAg-negative chronic hepatitis B

Karatayli S. C., Bozdayi M., Karatayli E., ÖZTÜRK T., Husseini A. A., ALBAYRAK DELİALİOĞLU R., ...More

LIVER INTERNATIONAL, vol.35, no.3, pp.846-853, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1111/liv.12595
  • Journal Name: LIVER INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.846-853
  • Keywords: hepatitis B infection, hepatitis delta infection, interferon lambda 3, interleukin 28 B, single nucleotide polymorphisms, GENOME-WIDE ASSOCIATION, NATURAL-HISTORY, CHRONIC HBV, HEPATOCELLULAR-CARCINOMA, ANTIGEN SEROCLEARANCE, INTERFERON-ALPHA, HLA-DP, VIRUS, IL28B, DELTA
  • Ankara University Affiliated: Yes

Abstract

Background & AimsAim of this study was to investigate whether a potential association exists between several single nucleotide polymorphisms (SNPs) of the IL-28B gene (rs12979860, rs1188122, rs8099917, rs8105790, rs12980275) and HBsAg persistence. Further, a potential effect on the development of HBeAg-negative CHB vs. inactive HBsAg carrier state was assessed in a genotype D HBV cohort. A cohort of chronic HDV patients was also used to see if they behave differently compared to chronic HBV patients.