A Very Rare Adverse Effect of Clozapine, Clozapine-induced Interstitial Lung Disease: Case Report and Literature Review

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Can K. C., KARNAK D., ÖZGÜVEN H.

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, vol.56, no.4, pp.313-315, 2019 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 56 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.29399/npa.23406
  • Journal Name: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.313-315
  • Keywords: Clozapine, interstitial lung disease, schizophrenia
  • Ankara University Affiliated: Yes

Abstract

Clozapine is the gold-standard antipsychotic agent for treatment-resistant schizophrenia. Yet with all its clinical efficacy, there are numerous adverse effects associated with clozapine. Although many, such as leucopenia and agranulocytosis, are well established, there is little published material on the drug's rare adverse effects. Among these, very little is known about clozapine-induced interstitial lung disease. Here we present such a case. We focus on its clinical aspects and discuss its relationship to the extant literature.