ARCHIVES OF PHARMACAL RESEARCH, cilt.27, sa.2, ss.156-163, 2004 (SCI-Expanded)
Some benzimidazole derivatives namely 1-[(substituted thiocarbamoylhydrazine carbonyl) methyl]-2-phenyl-1H-benzimidazoles (1a-13a), N-[(2-phenylbenzimidazol-1-yl methyl)-[1,3,4]thiadiazole-2-yl]-substituted phenyl amines (1b-13b) and 5-(2-phenyl benzimidazol-1-yimethyl)-4-substituted phenyl-4H-1,2,4-triazole-3-thiones (11c-13c) were synthesized, and their in vitro effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. The most active compound 10a caused an 84% inhibition of LP at 10(-3) M, which is better than that of butylated hydroxytoluene (BHT) (65%).