Synthesis and antioxidant properties of some novel benzimidazole derivatives on lipid peroxidation in the rat liver

Kus C., KILCIGİL G., EKE B., Iscan M.

ARCHIVES OF PHARMACAL RESEARCH, vol.27, no.2, pp.156-163, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1007/bf02980099
  • Journal Name: ARCHIVES OF PHARMACAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.156-163
  • Keywords: thiosemicarbazides, thiadiazolylmethylbenzimidazoles, triazolylbenzimidazoles, antioxidant, INDOLE, 1,3,4-THIADIAZOLE, AGENTS, 1,2,4-TRIAZOLE
  • Ankara University Affiliated: Yes

Abstract

Some benzimidazole derivatives namely 1-[(substituted thiocarbamoylhydrazine carbonyl) methyl]-2-phenyl-1H-benzimidazoles (1a-13a), N-[(2-phenylbenzimidazol-1-yl methyl)-[1,3,4]thiadiazole-2-yl]-substituted phenyl amines (1b-13b) and 5-(2-phenyl benzimidazol-1-yimethyl)-4-substituted phenyl-4H-1,2,4-triazole-3-thiones (11c-13c) were synthesized, and their in vitro effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. The most active compound 10a caused an 84% inhibition of LP at 10(-3) M, which is better than that of butylated hydroxytoluene (BHT) (65%).