Voltammetric investigation of oxidation of zuclopenthixol and application to its determination in dosage forms and in drug dissolution studies

Senturk Z., Ozkan S. A., Ozkan Y., Aboul-Enein H.

Journal of Pharmaceutical and Biomedical Analysis, vol.22, no.2, pp.315-323, 2000 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 2
  • Publication Date: 2000
  • Doi Number: 10.1016/s0731-7085(99)00291-5
  • Journal Name: Journal of Pharmaceutical and Biomedical Analysis
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.315-323
  • Keywords: zuclopenthixol, cyclic voltammetry, differential pulse voltammetry, glassy carbon electrode, formulation analysis, dissolution profile, IMPORTANT THIOXANTHENE DERIVATIVES, PERFORMANCE LIQUID-CHROMATOGRAPHY, CIS(Z)-CLOPENTHIXOL, FLUPHENAZINE, PLASMA, BLOOD
  • Ankara University Affiliated: Yes

Abstract

The oxidative voltammetric behaviour of zuclopenthixol (ZPT) at a glassy carbon has been studied using cyclic, linear sweep and differential pulse voltammetry. Oxidation of the drug produced three pH dependent anodic steps (representing an irreversible oxidation). Using differential pulse voltammetry, the drug yielded a well-defined voltammetric response in phosphate buffer, pH 5.2 at +0.82 V (vs. Ag/AgCl). This process could be used to determine ZPT concentrations in the range 8 x 10-7-2 x 10-4 M. The method was applied, without any interferences from the excipients, to the determination of the drug in tablets and oral drops, and in drug dissolution studies. (C) 2000 Elsevier Science B.V.