The effects of pressure and direct compression on tabletting of microsponges

Comoglu T., Gonul N., Baykara T.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, cilt.242, sa.1-2, ss.191-195, 2002 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 242 Sayı: 1-2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0378-5173(02)00155-2
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.191-195
  • Anahtar Kelimeler: microsponges, modified release, ketoprofen, direct compression, CONTROLLED-RELEASE, KETOPROFEN, PHARMACOKINETICS, MICROSPHERES, ENANTIOMERS
  • Ankara Üniversitesi Adresli: Evet

Özet

Microsponges are porous, polymeric microspheres that are used mostly for topical and recently for oral administration. Ketoprofen was used as a model drug for systemic drug delivery of microsponges in the study. Ketoprofen microsponges were prepared by quasi-emulsion solvent diffusion method with Eudragit RS 100 and afterwards tablets of microsponges were prepared by direct compression method. Different pressure values were applied to the tablet powder mass in order to determine the optimum pressure value for compression of the tablets. Results indicated that microsponge compressibility was much improved over the physical mixture of the drug and polymer and owing to the plastic deformation of sponge-like structure, microsponges produce mechanically strong tablets. (C) 2002 Elsevier Science B.V. All rights reserved.