Akademik Veri Yönetim Sistemi
REVUE ROUMAINE DE CHIMIE, cilt.60, sa.5-6, ss.427-445, 2015 (SCI-Expanded)
Antihypertensive drugs primarily affect systemic vascular resistance through producing vasodilation. This vasodilatory effect is achieved either by interference with sympathetic adrenergic vascular tone or by the blocking of the formation of angiotensin 11 or its vascular receptors. There are other antihypertensive drugs which have direct arterial dilatory or mixed arterial and venous dilatory effect. A survey of the literature published in analytical chemistry journals has been conducted and analytical methods which were developed and used for the determination of the antihypertensive drugs in their dosage forms and in biological samples have been reviewed in this paper. This review covers the time period from 2011 to present, during which over 125 recent analytical procedures including liquid chromatographic, spectrophotometric and voltammetric techniques were reported. The available information such as supporting electrolyte, pH, column, mobile phase, measuring or detection potential, sensitivity, selectivity etc. is given in the Tables.