In vitro and in vivo inhibition of myeloperoxidase with 5-fluorouracil

Akbiyik F., Demirpence E., KUZU M. A., Kilinc K.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, vol.57, no.9, pp.631-636, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 9
  • Publication Date: 2001
  • Doi Number: 10.1007/s002280100352
  • Journal Name: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.631-636
  • Keywords: myeloperoxidase, 5-fluorouracil, myelosuppression, PHASE-II TRIAL, POLYMORPHONUCLEAR LEUKOCYTES, COLORECTAL-CANCER, FOLINIC ACID, CHEMOTHERAPY, NEUTROPHIL, FLUOROURACIL, RECRUITMENT, PEROXIDASE, LEUCOVORIN
  • Ankara University Affiliated: Yes

Abstract

Objective: Myeloperoxidase (MPO) exists in neutrophils and has an important bactericidal role. During phagocytosis, MPO catalyzes a peroxidative reaction using chloride ion and hydrogen peroxide (H2O2) as substrate. The aim of the present study was to investigate whether 5-fluorouracil (5-FU), a chemotherapeutic agent, has a direct inhibitory effect on MPO and to evaluate some properties of this inhibition.