Antioxidant and Antifungal Properties of Benzimidazole Derivatives

KUŞ C., Sozudonmez F., EKE B., ÇOBAN T.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, vol.65, no.9-10, pp.537-542, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 9-10
  • Publication Date: 2010
  • Doi Number: 10.1515/znc-2010-9-1002
  • Journal Name: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.537-542
  • Keywords: Benzimidazole, Lipid Peroxidation, Superoxide Anion, LIPID PEROXIDE FORMATION, CHROMATOGRAPHY MASS-SPECTROMETRY, ASSAY, FLUCONAZOLE, OXIDATION, MEMBRANE, OXIDANTS, INCREASE, CANCER
  • Ankara University Affiliated: Yes

Abstract

Antioxidant and radical scavenging properties of a series of 2-[4-(substituted piperazin-/piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole derivatives were examined. Free radical scavenging properties of compounds 11-30 and 33 were evaluated for the stable free radical 2,2-diphenyl-1 -picrylhydrazyl (DPPH) and superoxide anion radical. In addition the inhibitory effects on the NADPH-dependent lipid peroxidation levels were determined by measuring the formation of 2-thiobarbituric acid reactive substances (TBARS) using rat liver microsomes. Compound 33 which has a p-fluorobenzyl substitutent at position 1 exhibited the strongest inhibition (83%) of lipid peroxidation at a concentration of 10(-3) M, while the nonsubstituted analogue 13 caused 57% inhibition. This result is fairly consistent with the antimicrobial activity results against both Staphylococcus aureus and Candida albicans.