ELECTROANALYTICAL METHODS FOR THE DETERMINATION OF PHARMACEUTICALS: A REVIEW OF RECENT TRENDS AND DEVELOPMENTS

USLU B., ÖZKAN S. A.

ANALYTICAL LETTERS, vol.44, no.16, pp.2644-2702, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 44 Issue: 16
  • Publication Date: 2011
  • Doi Number: 10.1080/00032719.2011.553010
  • Journal Name: ANALYTICAL LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2644-2702
  • Keywords: Cyclic voltammetry, Electroanalysis, Pharmaceutical products, Pulse techniques, Stripping techniques, CARBON-PASTE ELECTRODE, ADSORPTIVE STRIPPING VOLTAMMETRY, DIFFERENTIAL-PULSE VOLTAMMETRY, BORON-DOPED DIAMOND, SQUARE-WAVE VOLTAMMETRY, CONTINUOUS CYCLIC VOLTAMMETRY, SCREEN-PRINTED ELECTRODES, HUMAN BIOLOGICAL-FLUIDS, LEAD FILM ELECTRODE, MERCURY DROP ELECTRODE
  • Ankara University Affiliated: Yes

Abstract

Electroanalysis is a powerful analytical technique that is increasing in utility in the pharmaceutical industry. It is used as an alternative or complementary technique to spectrophotometric and separation techniques due to its high sensitivity, speed of analysis, reduction in solvent and sample consumption, and low operating cost compared to other analytical methods. A review of the principles and application of modern electroanalytical techniques, namely, cyclic, linear sweep, differential pulse, square wave and stripping voltammetric techniques, is presented. This review gives recent pharmaceutical analysis applications used for each mode of electroanalytical chemistry. The review will also describe recent developments for enhancing concentration limits of detection, electrode types, and so forth. Selected studies on these subjects are given as examples.