Cutaneous, pulmonary and hepatic sarcoidosis associated with autoimmune complications during interferon-alpha treatment for hepatitis C virus infection

Akay B. N., Ekmekci P., Sanli H., Celik G., Bozdayi M.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, vol.20, no.4, pp.442-445, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 4
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1468-3083.2006.01450.x
  • Journal Name: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.442-445
  • Keywords: chronic hepatitis C, interferon-alpha, sarcoidosis, CHRONIC MYELOGENOUS LEUKEMIA, LUNG LYMPHOCYTES-T, ALVEOLAR MACROPHAGES, THERAPY, THROMBOCYTOPENIA, GAMMA, PATIENT, RELEASE, CELLS
  • Ankara University Affiliated: Yes

Abstract

A patient with hepatitis C virus (HCV) infection was diagnosed with cutaneous, pulmonary and hepatic sarcoidosis following interferon alpha therapy. There are only a few cases of sarcoidosis associated with this treatment. This is the first case who not only developed sarcoidosis, but also autoimmune hypothyroidism and thrombocytopenia during interferon alpha therapy due to the immunomodulatory effects of the drug.