Synthesis, Molecular Docking Studies and Antibacterial Activities of Novel Monocationic Indole-benzimidazole Derivatives

Ates-Alagoz Z., KIŞLA M. M., Goker H., Yildiz S.

MEDICINAL CHEMISTRY, vol.17, no.7, pp.699-706, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.2174/1573406416666200420080459
  • Journal Name: MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.699-706
  • Keywords: Synthesis, indoles, benzimidazolecarboxamides, antibacterial activities, molecular docking, pyruvate kinase, RESISTANT STAPHYLOCOCCUS-AUREUS, MRSA PYRUVATE-KINASE
  • Ankara University Affiliated: Yes

Abstract

Background: Finding efficient therapy against hospital-acquired MRSA infections has become rather important in the last decade. To this end, inhibition of the enzyme pyruvate kinase (PK) is being investigated for antibacterial activity, since this enzyme controls energy generation and metabolic flux distribution. Our main scaffold consists of benzimidazole and indole rings fused together. Both rings are famous for antibacterial properties and promising anti-MRSA compounds including indole ring.