Evaluation of Efficacy of Long-term Growth Hormone Therapy in Patients with Hypochondroplasia

Cetin T., ŞIKLAR Z., Kocaay P., BERBEROĞLU M.

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.10, sa.4, ss.373-376, 2018 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4274/jcrpe.0043
  • Dergi Adı: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.373-376
  • Anahtar Kelimeler: Hypochondroplasia, growth hormone therapy, skeletal dysplasia, FACTOR RECEPTOR-3, PUBERTAL CHANGES, SHORT CHILDREN, MUTATION, PATTERN
  • Ankara Üniversitesi Adresli: Evet

Özet

Hypochondroplasia is a cause of disproportionate short stature and characterized by minor clinical manifestations. The aim of this study was to evaluate the efficacy of long-term growth hormone (GH) therapy in hypochondroplastic cases with inadequate response to GH stimulation tests. In this study, six patients who had a height standard deviation score of -3.43 before the treatment and a mean age of 7.42 years and who had received GH treatment at a dose of 0.2 mg/kg/week for a mean period of 4.45 years were evaluated. A good response was Found in the First year of treatment, but this increase was not found to be sufficient for the patients to achieve an adequate final height.