No relation between angiotensin-converting enzyme gene polymorphism and pseudoexfoliation.

Tekeli O., Turacli M. E., Altinok B., Akar N., ELHAN A. H.

Ophthalmic research, vol.40, no.1, pp.32-4, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1159/000111156
  • Journal Name: Ophthalmic research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.32-4
  • Keywords: pseudoexfoliation, glaucoma, angiotensin-converting enzyme, insertion/deletion polymorphism, INSERTION-DELETION POLYMORPHISM, OPEN-ANGLE GLAUCOMA, SYSTEM, EYE
  • Ankara University Affiliated: Yes

Abstract

Aims: To determine the association between the angiotensin-converting enzyme insertion/deletion (I/D) polymorphism and pseudoexfoliation (PEX) in Turkish patients. Methods: This prospective study consisted of 89 patients with PEX, and 120 controls. The I/D polymorphism of the angiotensin-converting enzyme gene was measured with the use of the polymerase chain reaction method. Results: The distribution of the polymorphism was not significantly different in cases with PEX and controls. The frequencies of the I and D alleles were not significantly different between the groups. Conclusion: According to our findings, I/D polymorphism in the angiotensin-converting enzyme gene does not play any role in the pathogenesis of PEX. Copyright (c) 2007 S. Karger AG, Basel.