Electroanalytical Studies and Simultaneous Determination of Amlodipine Besylate and Atorvastatine Calcium in Binary Mixtures Using First Derivative of the Ratio-Voltammetric Methods

DOĞAN TOPAL B., BOZAL PALABIYIK B., Demircigil B. T., USLU B., ÖZKAN S. A.

ELECTROANALYSIS, cilt.21, sa.22, ss.2427-2439, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 22
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/elan.200904689
  • Dergi Adı: ELECTROANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2427-2439
  • Anahtar Kelimeler: Amlodipine, Atorvastatine, Ratio derivative, Voltammetry, Pharmaceuticals, GLASSY-CARBON ELECTRODE, SPECTRA DERIVATIVE SPECTROPHOTOMETRY, PERFORMANCE LIQUID-CHROMATOGRAPHY, PHARMACEUTICAL FORMULATIONS, BIOLOGICAL-FLUIDS, BEHAVIOR, TABLETS
  • Ankara Üniversitesi Adresli: Evet

Özet

The electrochemical behavior of atorvastatin and amlodipine at a glassy carbon electrode has been studied using different voltammetric techniques. First derivative of the ratio voltammetric methods for determination of amlodipine and atorvastatin in tablets in the presence of the other compound has been described. This technique depends on the measuring of first derivative of the ratio voltammograms of each concentration as a function of the increased concentrations. DP and SW voltammetric methods depend on first derivative of the ratio-voltammetry by measurements of the selected potentials for amlodipine and atorvastatin. The linear response was within the range of 4 x 10(-6) -1 x 10(-4) M for amlodipine and 2 x 10(-6) -1 x 10(-4) M for atorvastatin. The proposed methods have been extensively validated.