High CD95 expression of BAL lymphocytes predicts chronic course in patients with sarcoidosis

Ozdemir Ö., ÇELİK G., Dalva K., Ulger F., ELHAN A. H., BEKSAÇ M.

RESPIROLOGY, vol.12, no.6, pp.869-873, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1440-1843.2007.01151.x
  • Journal Name: RESPIROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.869-873
  • Keywords: CD45RO, CD95, prognosis, sarcoidosis, BRONCHOALVEOLAR LAVAGE FLUID, T-CELL SUBSETS, PULMONARY SARCOIDOSIS, FAS CD95, APOPTOSIS, DISEASE, PROGNOSIS
  • Ankara University Affiliated: Yes

Abstract

Background and objective: The prognosis of sarcoidosis is highly variable, with spontaneous remission in some patients. Apoptosis may be associated with spontaneous resolution of the granulomata. CD95 (Fas), an apoptotic molecule, and CD29 and CD45RO (T-cell memory markers) are expressed at higher levels on T lymphocytes from sarcoid patients compared with normal subjects. However, the prognostic significance of CD95, CD29 and CD45RO expression in sarcoidosis is not clear. It was hypothesized that expression of CD95 would correlate with spontaneous remission.