Borderline congenital hypothyroidism in the neonatal period

ŞIKLAR Z., Tezer H., Dallar Y., Tanyer G.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.15, sa.6, ss.817-821, 2002 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 6
  • Basım Tarihi: 2002
  • Dergi Adı: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.817-821
  • Anahtar Kelimeler: prolonged jaundice, neonate, congenital hypothyroidism, TRH stimulation test, BILIARY ATRESIA, JAUNDICE, INFANTS
  • Ankara Üniversitesi Adresli: Hayır

Özet

One of the most important etiological factors causing prolonged jaundice in the neonatal period is congenital hypothyroidism. Some infants may have abnormal, thyroid function test results rather than overt congenital hypothyroidism. Although serum TSH levels are accepted as diagnostic when >20 muIU/l, TSH values higher than 7 muIU/ml cause a hypometabolic condition. In this study, we evaluated infants who had prolonged jaundice for hypothyroidism. A hundred and ten infants suffering from prolonged jaundice were admitted to our clinic during the study period. Among them, 61 infants had normal thyroid function results. Six patients had overt primary hypothyroidism. TRH stimulation test was administered to the 43 patients with mildly elevated TSH levels of between 5 and 20 muIU/ml. Peak TSH values were above 35 muIU/ml in seven patients, and these were considered as having an exaggerated response (borderline hypothyroidism). During the neonatal period, prolonged jaundice is a valuable diagnostic clue for hypothyroidism. In addition, the TRH stimulation test can be a diagnostic tool in evaluating infants with mildly abnormal thyroid function test results.