Sulphasalazine-induced hypersensitivity syndrome

Saral S., AKAY B. N., ŞANLI H.

TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY, vol.47, no.2, pp.123-125, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.4274/turkderm.22590
  • Journal Name: TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.123-125
  • Keywords: Hypersensitivity, HHV-6, sulphasalazine, hepatitis, TOXIC EPIDERMAL NECROLYSIS, INDUCED DRESS SYNDROME, SYSTEMIC SYMPTOMS, DRUG RASH, REACTIVATION, EOSINOPHILIA, FEATURES, DANGER
  • Ankara University Affiliated: Yes

Abstract

Drug-induced hypersensitivity syndrome (DIHS) is one of the most dangerous drug reactions. Mortality and morbidity is increased by consequent systemic organ involvement. Maculopapular eruptions are the most common lesions accompanying DIHS, however, the morphology of skin lesions may vary. The most common cause of DIHS is the use of aromatic anticonvulsant drugs. However, one must not forget that other drugs may also cause DINS. Early recognition of the condition is the most important step in the treatment. Herein, we present a case of DINS triggered by sulphasalazine and associated with pustular eruption and maculopapular eruption.