Postoperative analgesia in impacted third molar surgery: The role of preoperative diclofenac sodium, paracetamol and lornoxicam

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Tuzuner Oncul A. M., Yazicioglu D., Alanoglu Z., Demiralp S., Ozturk A., Ucok C.

Medical Principles and Practice, vol.20, no.5, pp.470-476, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.1159/000327658
  • Journal Name: Medical Principles and Practice
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.470-476
  • Keywords: Preemptive analgesia, Diclofenac sodium, Intravenous paracetamol, Lornoxicam, Third molar surgery, PREEMPTIVE ANALGESIA, PAIN MANAGEMENT, DIFLUNISAL, INHIBITORS, IBUPROFEN, REMOVAL, RELIEF, BLIND
  • Ankara University Affiliated: Yes


Objective: The aim of this study was to compare the postoperative analgesic effects of preoperative intravenous (i.v.) paracetamol, diclofenac sodium and lornoxicam (nonsteroidal anti-inflammatory drugs). Subjects and Methods: Sixty patients with impacted third molar who underwent surgical removal were randomly allocated into three groups: group P (n = 20), group D (n = 20) and group L (n = 20). Group P received preoperatively 1 g paracetamol i.v., group D 75 mg diclofenac sodium i.m. and group L 8 mg lornoxicam i.v. Postoperative pain intensity, additional consumption of analgesics postoperatively and postoperative complications were compared among groups. Results: The groups were comparable for pain scores (p > 0.05). Maximum pain scores were recorded in postoperative 4th h in all groups (group L 22, 14-44 mm; group P 24, 13-43 mm; group D 14, 10-24 mm, p = 0.117). Patients experienced high satisfaction scores which were comparable among groups (group L 85, 75-100 mm; group P 87, 70-95 mm; group D 84, 77-98 mm, p = 0.457). Conclusion: Preoperative intramuscular diclofenac, intravenous paracetamol and lornoxicam effectively decreased the pain scores. The patients were satisfied with the three postoperative pain management regimens. Copyright © 2011 S. Karger AG, Basel.