Investigation of polymorphic variants of SLC6A4 TPH-1, and TPH-2 genes in cases of completed suicide

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Kilicaslan D. Y., Cumaogullari O., Emiral E., Tezer N., Öncü Çetinkaya B., Özdağ Sevgili H., ...More

JOURNAL OF MENS HEALTH, vol.18, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18
  • Publication Date: 2022
  • Doi Number: 10.31083/jomh.2021.116
  • Journal Name: JOURNAL OF MENS HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Suicide, Polymorphism, KASP, TPH-1, TPH-2, SEROTONIN TRANSPORTER GENE, SINGLE-NUCLEOTIDE POLYMORPHISMS, SHORT-TERM RISK, DEPRESSIVE DISORDER, HAPLOTYPE ANALYSIS, FAMILY-HISTORY, LIFE STRESS, ASSOCIATION, BEHAVIOR, CHILDHOOD
  • Ankara University Affiliated: Yes

Abstract

Background and objective: Serotonin plays an important role in the pathophysiology of aggressive behavior. Low serotonin levels and altered functions of serotonin receptors affect suicidal behavior. TPH-1, TPH-2 and SLC6A4 genes have important roles in serotonin production and degradation pathways. In this study, polymorphic variants of the TPH-1, TPH-2 and SLC6A4 genes, rs1800532, rs7305115, rs6355 and rs1386494, were investigated in 100 completed suicides and 100 healthy individuals.