Lipid peroxidation and scavenging enzyme levels in the liver of streptozotocin-induced diabetic rats

Bukan N., Sancak B., Yavuz O., Koca C., Tutken F., ÖZÇELİKAY A. T., ...More

INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, vol.40, no.6, pp.447-450, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 6
  • Publication Date: 2003
  • Journal Name: INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.447-450
  • Keywords: lipid peroxidation, antioxidant enzymes, diabetic rats, SUPEROXIDE-DISMUTASE ACTIVITY, GLUTATHIONE-PEROXIDASE, FREE-RADICALS, SULFONYLUREA GLYBURIDE, OXIDATIVE STRESS, HUMAN-DISEASE, CATALASE, INACTIVATION, REDUCTASE, MELLITUS
  • Ankara University Affiliated: Yes

Abstract

In this study, alterations in the liver antioxidant enzymes status and lipid peroxidation in short-term (8-weeks) and long-term (24-weeks) diabetic rats were examined. Glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) levels were significantly increased, but superoxide dismutase (SOD) activity was significantly reduced in 8-weeks diabetic rats, compared to control. Catalase (CAT) activity, however, was found unchanged. In 24-weeks diabetic rats, while GSH-Px activity was unchanged, but SOD and CAT activities and MDA levels were significantly increased, compared to control. These results suggest that diabetes-induced alterations, in tissue antioxidant system may reflect a generalized increase in tissue oxidative stress. It can be concluded that lipid peroxidation and antioxidant enzyme levels are elevated in diabetic condition. Hence, diabetes mellitus, if left untreated, may. increase. degenerative processes. due. to accumulation of oxidative. free radicals.