Electroanalytical study of nifedipine using activated glassy carbon electrode

Senturk Z., Ozkan S. A., Ozkan Y.

Journal of Pharmaceutical and Biomedical Analysis, vol.16, no.5, pp.801-807, 1998 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 5
  • Publication Date: 1998
  • Doi Number: 10.1016/s0731-7085(97)00120-9
  • Journal Name: Journal of Pharmaceutical and Biomedical Analysis
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.801-807
  • Keywords: nifedipine, voltammetry, activated glassy carbon electrode, pharmaceutical formulations, LIQUID-CHROMATOGRAPHIC DETERMINATION, QUANTITATIVE-ANALYSIS, GOLD ELECTRODE, PLASMA, NITROBENZENE, METABOLITES, REDUCTION, PHOTODECOMPOSITION, DIHYDROPYRIDINES, PHOTODEGRADATION
  • Ankara University Affiliated: Yes

Abstract

The electrochemical properties of nifedipine have been investigated in aqueous solution by linear sweep and cyclic voltammetry. The method is based both on the reduction and on the oxidation of the drug at a glassy carbon electrode activated by applying a new pre-treatment. The voltammograms of nifedipine on pH, concentration and scan rate have been carefully examined. Both the electroreduction and electrooxidation of nifedipine allow its determination at pH 1.5 in the concentration range of 2 x 10-5-6 x 10-4 M and 8 x 10-5-1 x 10-3 M, respectively. The method has been applied to commercial samples (tablets and capsules).