Imprinted Polymers on the Route to Plastibodies for Biomacromolecules (MIPs), Viruses (VIPs), and Cells (CIPs)


Zhang X., Yarman A., Bagheri M., El-Sherbiny I. M., Hassan R. Y. A., KURBANOĞLU S., ...More

Advances in biochemical engineering/biotechnology, vol.187, pp.107-148, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 187
  • Publication Date: 2024
  • Doi Number: 10.1007/10_2023_234
  • Journal Name: Advances in biochemical engineering/biotechnology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Page Numbers: pp.107-148
  • Keywords: Biomimetic sensors, Cell-Imprinted Polymers (CIPs), MIPs for proteins and nucleic acids, Plastibodies, Virus-Imprinted Polymers (VIPs)
  • Ankara University Affiliated: Yes

Abstract

Around 30% of the scientific papers published on imprinted polymers describe the recognition of proteins, nucleic acids, viruses, and cells. The straightforward synthesis from only one up to six functional monomers and the simple integration into a sensor are significant advantages as compared with enzymes or antibodies. Furthermore, they can be synthesized against toxic substances and structures of low immunogenicity and allow multi-analyte measurements via multi-template synthesis. The affinity is sufficiently high for protein biomarkers, DNA, viruses, and cells. However, the cross-reactivity of highly abundant proteins is still a challenge.