Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles

ALP M., GÖKER A. H., ALTANLAR N.

TURKISH JOURNAL OF CHEMISTRY, vol.38, no.1, pp.152-156, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.3906/kim-1303-81
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.152-156
  • Keywords: 1H-Benzimidazole, antimicrobial activities, methicillin resistant Staphylococcus aureus, Candida albicans, STAPHYLOCOCCUS-AUREUS MRSA
  • Ankara University Affiliated: Yes

Abstract

A new class of 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles (13-22) were synthesized via cyclocondensation reaction of the substituted 1,2-phenylenediamines (1, 4-12) and 1-(4-formylpheny)-1H-benzimidazole (3). The synthesized compounds were evaluated for antibacterial and antifungal activities against S. Atreus, methicillin-resistant Staphylococcus Atreus (MRSA), and Candida albicans by the tube dilution method. Compounds 13, 15, 18, 20, and 21 have moderate antifungal activity against C. albicans.